@ rel4x
Which version do you use?
1) Enable logs, there should be a problem reported.
when e+ is closed edit preferences.ini and set following values:
QUOTE(preferences.ini)
[eMule]
Verbose=1
LogToFile=1
BugReport=1
CMNotLog=1
start e+ and when it happens again, open debug.log and lookout for errors and "exception"
2) Try to delete known.met file in the config directory.